Balancing neurotransmitters (otherwise known as correcting disrupted brain chemistry) is one of the issues I work the most on with my clients. Simply because neurotransmitters are involved in pretty much every aspect of health, but especially when we are dealing with conditions like Candida, SIBO, IBS, and other functional gut disorders, adrenal fatigue, depression, anxiety disorders, OCD, or any other mental health issue, excess sympathetic nervous system activity (aka sympathetic dominance), sugar and carb addiction, compulsive overeating or binge eating, or drug and alcohol addiction.
In a nutshell, neurotransmitters are naturally occurring chemicals in the brain used by neurons to transmit information throughout the brain and body. For example, neurotransmitters instruct your heart to beat, your lungs to breathe, and your gastrointestinal system to digest your food. They also modulate mood, sleep cycle, stress, appetite, weight, cognitive functions, speech, perception, motor functions, self-esteem, energy levels, pain, sexual arousal and desire, and more.
Neurotransmitters are also intricately involved with spirituality, quality of life, and interpersonal relationships, as they are what enables us to experience inner peace, feelings of well-being, serenity, empathy and compassion, regulation of impulsivity and aggressiveness, bonding with self and others, and to experience deep purpose and meaning in life and connection to whatever spiritual belief we hold. You can learn more about the basics of these amazing little substances on the following page.
There are two types of neurotransmitters – excitatory (stimulates) and inhibitory (calms). Serotonin, GABA, and endorphins/enkephalins are our primary inhibitory neurotransmitters. Norepinephrine, epinephrine, glutamate, and histamine are the primary excitatory. Acetylcholine and dopamine can be inhibitory or excitatory. Like most things in life, neurotransmitters need to remain balanced for optimal health. Too much or too little in either direction can lead to significant impairment in mental, physical, and/or spiritual health.
Neurotransmitters are also formed in and used by the gut or the alimentary canal (from the esophagus to anus) and are known as the enteric nervous system. For example, serotonin and GABA play a critical role in gut motility and other digestive functions. However, it’s important to note that the brain cannot use the neurotransmitters formed in the gut. Neurotransmitters used by the brain must be formed in the brain, but the gut can affect the brain through the vagus nerve.
Two Basic Principles Involved in Balancing Neurotransmitters.
- Remove the elements that disrupt brain chemistry. There are numerous elements that can ramp up, deplete, inhibit, or disrupt normal neurotransmitter production or function. In order to achieve and maintain balance, these factors need to be eliminated.
- Give the brain what it needs to produce and transmit neurotransmitters adequately. The bottom line is that the brain needs a specific set and amount of nutrients in order to produce neurotransmitters and for them to transmit properly. These nutrients are acquired through your diet. If these nutrients are not supplied in adequate numbers in your diet on a daily basis, then production and function will be impaired.
However, within these two principles there can be hundreds of aspects that may contribute to imbalances in neurotransmitters. Here are the primary issues that should be explored and addressed.
Eliminate Mind-Altering Substances
The first step is to get rid of the substances that impair brain chemistry. All the following substances disrupt neurotransmitter function and/or production and should be avoided.
- all psychotropic drugs (cocaine, meth, heroin, lsd, etc.)
- marijuana (including medical marijuana or cannabis oil)
- antidepressant medication (Zoloft, Prozac, etc.)
- anti-anxiety medication (e.g. Ativan, Xanax, Klonopin, and other benzodiazepines)
- sleep medication (e.g. Ambien, etc.)
- ADHD medication
- caffeine (including coffee and green tea)
- sugar (all types, including honey and coconut sugar)
- chocolate (including dark or raw cacao)
- high carb foods (potatoes, anything starchy)
- artificial sweeteners
- artificial flavorings, dyes, preservatives, additives
The balance of neurotransmitters cannot be obtained if one is engaging with any of the aforementioned substances. Even if you eat the correct diet and do everything suggested on this page, you are not likely to see significant improvements if these aspects are not removed.
Diet for Balancing Neurotransmitters
The primary nutrients the brain needs for adequate production and transmission of neurotransmitters is acquired through animal protein and fat. Animal protein provides amino acids and other nutrients for formation and fat is required for transmission. The diet that balances the brain is a low-carb Paleo diet that is individualized for your unique needs.
All plant-based sources of animal protein are either incomplete or inferior. Protein and fat should come primarily from animal sources. Most fat should be saturated fat and complemented with monounsaturated fat. It’s equally important to maintain a balance between omega-3 and omega-6 fatty acids, also best acquired through animal protein.
Cholesterol is also vital for normal brain function. It is a basic building block in the membrane of brain cells, provides fuel for neurons, and aids in neuron function. So, again another reason animal protein is so important. Cholesterol interacts with sunshine to produce vitamin D, which is another vital nutrient for adequate brain function.
Carb intake for the day should not exceed 60 to 70 grams at most. Many people feel better under 50 grams per day. If one is attempting to overcome sugar and carb addiction, compulsive overeating, or binging, then carb intake almost always needs to be under 50 grams per day. High carb foods initially cause a big surge in neurotransmitters, and when eaten daily, this leads to tolerance and depletion and then addiction to carbohydrates.
High carb meals are also a form of stress on the body, as they will initially cause a rise in blood glucose and then a drop. Both of these scenarios set off the stress response system, which as discussed further below, also leads to the depletion of neurotransmitters. Additionally, high blood sugar caused by the consumption of carbohydrates is associated with significant brain shrinkage, like that found in Alzheimer’s individuals.
All three meals per day should contain a minimum of four ounces of animal protein and as much as eight ounces. Consume however much is needed to feel satiated in combination with fat. The lower the carb intake the higher the animal protein and fat. When the diet goes under 50 grams per day, then eight ounces of animal protein in each meal is typically required.
Meals should be no more than five hours apart. In End Your Addiction Now, Dr. Charles Gant explains that we experience hunger as an unpleasant event because there is a decline in neurotransmitters.
If snacking is needed in between meals, snacks should consist of animal protein and fat. (e.g. hamburger, hard-boiled egg, chicken thigh, a piece of steak)
It is critical to keep blood sugar stable, as when blood sugar drops, there is an increase in the excitatory norepinephrine and a decrease in inhibitory neurotransmitters. Blood sugar is kept stable with animal protein and fat and eating those meals consistently three times a day.
No sugar. Sugar is a drug that depletes neurotransmitters. ( This includes honey, maple syrup, coconut sugar, etc.)
Low-carb vegetables in moderation. (No high starch foods like potatoes. A medium-sized potato is the equivalent of a half cup of sugar.)
Nuts, seeds, and low-sugar fruit in moderation or strictly limited.
Butter, ghee, and heavy cream are acceptable forms of dairy unless one has an autoimmune condition, is intolerant of dairy, or has problems with dairy exorphins, which you can learn about on this page.
The diet should be free of alcohol, caffeine, chocolate, grains, legumes, milk products with lactose, high carb foods, as mentioned previously, all of these disrupt neurotransmitters.
Please note that corn is a grain, not a vegetable. Peas are a legume, not a vegetable. Peanuts are a legume, not a nut. So, each of these is eliminated.
You should also explore whether you are dealing with high histamine or high glutamate and, if so, then moderate consumption of those foods as well.
Take a look at the following page for more guidance on designing and personalizing your Paleo diet.
Avoid Mind-altering Herbs
There are a wide variety of herbs that can impair neurotransmitter function and production as well. Some of them include but are not limited to, St. John’s wort, Olive Leaf, curcumin, valerian root, passionflower, holy basil, kava kava, etc.
Herbs affect the brain in a similar manner as prescription-based drugs, the brain responds by down-regulating production of or responsiveness to the neurotransmitter with ongoing use of these substances, thus perpetuating the imbalance.
Clean Up Environmental Toxins
There is nothing more harmful to the brain than pesticides and herbicides. They can cause depletion of dopamine, serotonin, endorphins, GABA, and oxytocin, and an excess of glutamate, acetylcholine, histamine, and norepinephrine. They also cause an increase in blood glucose. Pesticides damage the brain.
The home and yard should be completely free of pesticides and herbicides. Do not live in farming areas or communities that do aerial spraying for mosquitoes etc.
Other common everyday chemicals found in your cosmetics, household cleaning supplies, air fresheners, disinfectants, personal care products, laundry soap, dish soap, can all disrupt brain chemistry. All these products should be natural, non-toxic, and environmentally friendly.
Make sure your sheets and blankets are not washed in chlorine bleach, it is a major neurotransmitter disruptor.
If the environmental toxin aspect is ignored, you are not likely to see any improvements, regardless of what other steps you take.
Within this category, one should also assess heavy metal status. Heavy metals can impair neurotransmitter production or function. For example, too much copper can impair the synthesis of serotonin and GABA. Mercury and other toxic metals can cause chronic excess sympathetic nervous system activity.
When we are under stress, we have a greater need for neurotransmitters, because they are what help us cope with the stressful situation and return to the non-stress (parasympathetic) state.
If stress is ongoing, then many inhibitory neurotransmitters like dopamine, endorphins, GABA, and serotonin can become depleted and we can end up in a chronic state of excess sympathetic nervous system activity.
We all have an immense amount of stress so a variety of stress management techniques like mindfulness meditation and deep breathing exercises, communing with nature, smiling, should be built into our lives on a daily basis.
Practice Mindfulness and Deep Breathing
The regular use of mindfulness and deep breathing are excellent tools for increasing the inhibitory neurotransmitters Gaba, serotonin, endorphins, and dopamine and lowering the excitatory neurotransmitters, thus reducing stress, increasing parasympathetic nervous system activity, calming the mind, and an abundance of other benefits. They are vital in the quest for balancing neurotransmitters and should be practiced faithfully and consistently. At a minimum, they should be practiced daily every morning when you get up and every night when you go to bed. You can learn how to do them both quickly and easily in the following resource.
Assess Microbial Overgrowth
Overgrowth of bacteria, yeast, viruses, or parasites can all cause major disruption to the production or function of neurotransmitters. Toxins produced by microbes may alter neurotransmitter production or function and it appears the microbes themselves may be able to tap into our transmission system. Many microbes can produce false neurotransmitters. Each of these issues should be explored to see if they are applicable to your situation. If they are, then they should be addressed accordingly.
Microbial overgrowth is a very common cause of imbalance in neurotransmitters, and thus a wide array of psychological disorders and gastrointestinal conditions.
Get Adequate Sleep
When we don’t get enough sleep, neurons lose sensitivity towards neurotransmitters, which makes them less effective. Additionally, stress hormones are elevated when we are sleep-deprived, which then creates a higher demand for neurotransmitters. And, the brain flushes itself of waste proteins that accumulate between brain cells during the day while we sleep.
Although exercise is crucial for all aspects of health, including brain health, too much exercise or the wrong type can deplete inhibitory neurotransmitters and cause an elevation in norepinephrine or histamine, and contribute to excess sympathetic nervous system activity.
Chronic cardio, traditional aerobics, marathon running, or any type of endurance exercise are experienced as stress on the body, which as we established above drains neurotransmitter levels.
Exercise should be mild and gentle. Low-impact most of the time with an occasional burst of high-intensity. High-intensity should be brief and followed by rest and recovery. How much you exercise should be guided by what is comfortable for your body. If you feel worse after you exercise, you have pushed too hard.
Get Adequate Sunshine
Sunlight stimulates the release of neurotransmitters. However, it also interacts with cholesterol in the body to form vitamin D that is needed for regulating enzymes in the brain and cerebrospinal fluid associated with activating nerve growth and the construction of neurotransmitters. Vitamin D also protects neurons from free radicals and inflammation.
Consider Possible Supplementation
Amino acid supplementation with the required vitamin and mineral co-factors can be used in some cases to help restore balance to neurotransmitters. For example, dopamine needs tyrosine iron, niacin, folic acid and B6 (p5p), and it needs vitamin c, copper, sam-e, and magnesium to break down. Serotonin needs tryptophan, iron, folic acid, B3, B6 (p5p), chromium, and vitamin C and it needs B5 and sam-e to break down. Acetylcholine needs choline and B5. Endorphins/enkephalins need l-leucine, methionine, glycine, tyrosine, and a multi-mineral with copper. GABA needs glutamine, B6 (p5p), magnesium, taurine, and vitamin C. Other minerals like zinc are typically needed for all of these.
However, not everyone responds positively to supplementation. Some supplements meant to increase GABA, like glutamine or GABA itself, can actually increase glutamate instead. 5HTP used to increase serotonin can increase cortisol or norepinephrine. Tyrosine or phenylalanine used to increase dopamine or endorphins can increase norepinephrine. Experiment cautiously and adjust accordingly.
Assess whether digestive enzymes are needed. A lack of hydrochloric acid or other digestive enzymes can result in sub-optimal levels of amino acids required for the production of neurotransmitters, due to impaired digestion.
Commune with Nature
Spending time in nature stimulates calming inhibitory neurotransmitters that lower stress and modulate mood. It’s also a great way to get your daily dose of sunshine needed for vitamin D production and a supreme place for practicing mindfulness. Get out at least several times a week, or more if possible.
Explore Genetic Polymorphisms
There are a wide variety of genetic polymorphisms that can affect the production or function of neurotransmitters. Genomics testing can be used to identify these issues. However, keep in mind that the most important aspect in regard to how a genetic polymorphism is expressed is influenced by the diet you eat and the toxins in your environment, and other lifestyle factors. So the best way to help a genetic issue is to eat a primal diet and live in a clean environment as we already discussed.
Avoid Toxic People
The people we surround ourselves with have a profound impact on our brains. Narcissists, psychopaths, sociopaths, abusers of all kinds, and people who are cold, calloused, harsh, and lacking in compassion damage the brain just like a toxin. They elevate norepinephrine levels and cortisol levels and keep us in a perpetual state of stress. Be very careful about who you allow in your life.
Balancing Neurotransmitters is an Ongoing Event
The modern world in which we live promotes an imbalance in neurotransmitters. If you live the typical lifestyle of the average individual in our society, then you will be swimming in a sea of mind-altering toxins, drowning in stress, barely keeping your head above water with a nutrient-depleted diet and medicating all the consequences of these actions with a vast array of pharmaceuticals. All of which makes it impossible to have properly functioning brain chemistry.
Keeping neurotransmitters in balance requires constant vigilance and an ongoing concerted effort to remain deeply committed to the proper diet and lifestyle as discussed. It is a life-long process, not something you do just once.
Charles Gant, M.D. End Your Addiction Now.
Dr. David Perlmutter. Grain Brain
24 thoughts on “Balancing Neurotransmitters Checklist”
Thank you for this article. Do you find balance issues (feeling like I’m always on a boat, dizzy at times, not stable on feet) to be a common issue? I feel this way 90% of the time. I’ve been treating Candida, Sibo, gut, along with diet and environment for years now.
That sounds like it may be high histamine, which is very common in people with candida and sibo. You can learn more about high histamine on the following page.
Great article! I like both the information in it and its spiritual orientation.
It is very difficult to give up the dark chocolate. It is such a temptation! Some doctor said that the safe dose per day is between 6-25 grams of chocolate. That’s roughly one vertical strip of a normal chocolate block of 100 g (normally it has 6 such strips).
And I am an active master athlete (jumps and sprints), at age 52. I know that such intensive exercises are unhealthy. Sympathetic dominance (dysautonomia) is one of the problems I experience. I try to limit training to 2 workouts of 1 hour per week, plus maximum 3-4 competitions per year. but can’t cut it completely from my life. It gives sense to my life.
So, I feel like a smoker who knows that smoking is harmful but continues to smoke.
Clean air and contact with nature (preferably in the mountain) are a must for restoring the normal functioning of the nervous system and improving the health in general.
Moving to live in the countryside is a crucial step in that direction. Unfortunately, nowadays many people are stuck to the cities because of their jobs.
Again, thank you for the article and for making me rethinking my lifestyle!
Thank you Ventsi.
The reason chocolate is hard to give up is because it is an addictive, mind-altering drug. It is loaded with hundreds of mind-altering chemicals, that disrupt and deplete neurotransmitters. It affects the brain in a similar manner as marijuana, cocaine, opiates, and alcohol. It is also high in caffeine and other stimulant drugs that perpetuates sympathetic dominance. You can read about chocolate on the following page.
I, too, have that horrible rocking boat sensation and walking and balance very affected. Sibo, Lyme, Babesiosis and Mold exposure… hard to treat as so reactive to herbs. Question about lecithin and phosphatidylserine or choline, are they not good for the brain when it is so affected by gut and infections? And why is curcumin not so good, looking at a one that is mixed with lecithin. Thanks so much, your post is brilliant and very helpful.
Well lecithin, phosphatidylserine and choline could be beneficial if the person needs to increase their acetylcholine. If not, then could be counterproductive. Phosphatidylserine can also be beneficial for lowering cortisol, if it is high.
Curcumin has many benefits such as lowering inflammation and as an antimicrobial. However, it also targets dopamine and serotonin in a similar manner as antii-depressants. Anything that artifically or excessively stimulates neurons incites the brain to down-regulate production of or responsiveness to said neurotransmitter. Therefore, it has the potential of contributing to an imbalance in neurotransmitters.
One must weigh the benefits against the negatives to determine if an herb should be used. Sometimes an herb that affects neurotransmitters can be used for a short period of time.
I am healing from adrenal fatigue and am on a low inflammatory diet. I have high stress and am heterzygous for both MTHFR C677T and A1298C, one copy of each. I am extremely nervous and anxious. Would you recommend supplementing glutathione? I believe I have excess glutamate and taking supplemental GABA makes all this worse.
You should read the following page on GABA and glutamate.
Is there a way to test your neurotransmitters? If so, what is the recommended one? Thanks
You want to stay away from tests that use blood or urine to measure the actual neurotransmitter levels. They are not reliable. Cerebrospinal fluid is the
Cereobrospinal fluid (CFS) is the only method that can tell us the actual level of neurotransmitters in the brain. Blood platelet testing results corresponds very closely to CFS, but only for dopamine, norepenephrine, and serotonin, – not GABA or endorphins.
Questionnaires are often reliable, such as the one found in End in Your Addiction Now or The Mood Cure.
The Organic Acids Test will tell you about serotonin, dopamine and norepinephrine.
Histamine can be measured with blood histamine test.
Wow great information!
I was taking low dose of Xanax for several years and stopped a few months ago and had trouble so now tapering down and learning about gaba and nutrition. This answered several of the questions I had.
Still curious about animal proteins/fats with regards to cholesterol. Probably from things I’ve heard in the past to stay away from red meat. But I am working it in and was just looking at beef and there was an option 15% or 7% fat, need to make new decisions now 🙂
Thanks for the great information
There is no risk with cholesterol etc. when eating animal protein and fat. It is carbs that cause those problems. Please read Grain Brain by Dr. David Perlmutter. The Art and Science of Low Carbohydrate Living by Dr. Phinney and Volek. The Primal Blueprint by Mark Sisson.
Like the comprehensiveness of your article. It’s very informative. However, I felt frustrated after reading your advice about eliminating mind-altering herbs. I suffer from severe insomnia due to a couple of bouts with on-going stress. If I eliminate these herbs, I sleep only two hours, which will result in further issues with neurotransmitter imbalance as based on your advice about getting adequate sleep. So seems like I am in a vicious cycle. Related to diet, I do the ketogenic diet so I have no grain and no sugar except from berries in the morning. My diet consists of quality fat, animal protein and low starch veggies and greens and my beverage is spring water. Can you please advise how to get adequate sleep until one’s neurotransmitters are back in balance because from reading your advice, it doesn’t seem possible. Thank you.
If you’re still not able to sleep with the changes you’ve made, you’re missing some of the pieces of your puzzle. You need to be looking at what underlying contributors are causing your problem. The two best places to start are SIBO and Candida overgrowth. These two issues are very common in people with sleep problems. There are links to more info on these topics in the article above. Genetic issues and methylation are other areas to look.
I have been enjoying browsing your website and found it when researching the Annie Hoppers DNRS program so read your review of the Gupta and DNRS brain training programs. I liked this particular article about balancing neurotransmitters as I feel I have very low levels of these and you talk about ways to naturally improve levels of neurotransmitters. I’ve been working with a functional medicine practitioner for a couple of years now and have seen a lot of improvements with cleaning up my diet and removing pathogens from my gut (and I had a lot of them!) but I seem to be stalled right now. I have been having a difficult time trying to wean off of 5HTP for anxiety. It is a background anxiety that is always there (sometimes much worse when under stress) and my body always feels tense especially around my jaws and neck and it is hard for me to relax. The 5HTP takes the edge off this feeling of being hypervigilant all the time. I have come to realize that my childhood adverse experience of having a very domineering and frightening father probably caused this state of anxiety and I am now seeking ways to try to reverse this as my way forward. I decided talk therapy was not the solution for me as I think this started before I was forming historical memories. I am using Holosync (which seems to help some) for meditation as I find plain vanilla meditation hard to stick to. I am trying to get in touch with my emotions more – most of the time I don’t know what I feel (except anxious), and am thinking about somatic experiencing and myofascial release to work on the physical side of the tension. I am curious as to whether the Gupta Amygdala or DNRS would help to to build new pathways in my brain too. Do you know of anyone who has had success using these for anxiety?
Keep up the good work – and I subscribed to your newsletter so look forward to receiving those.
Yes, absolutely. Anxiety is one of the primary symptoms that DNR and Gupta helps alleviate.
Will having hypothyroidism imbalance the neurotransmitters? Will cytomel T3 help? Since taking and adding gaba I feel better. At one time I was on amitriptyline and believe this was a great cause to my imbalance.
Yes, hypothyroidism can affect neurotransmitters and vice versa.
Neurotransmitters are needed for the modulation and syntheses of the thyroid-stimulating hormone; while on the other hand, the production of serotonin is dependent upon the thyroid. Additionally, hypothyroidism alters the manner in which the brain uses these neurotransmitters.
Hypothyroidism is typically best treated with a natural thyroid extract, containing T4 and T3. And supporting adrenals. You can read more on the following page.
Thank you for another wonderful and informative article! I’m learning so much from you! It’s really surprised me to read here that curcumin can disrupt neurotransmitters. I’ve been taking it for several years to help with inflammation and my candida overgrowth problem, but now want to stop taking it after reading your article. The only problem is every time I try to skip even one day of taking it my candida flares up. Any suggestions for me? This actually happens to me whenever I try to stop taking any of my supplements, not just the curcumin.
You’re welcome. If you don’t have a negative response to curcumin, and it is helping you then, probably okay for you. It has many positive benefits as well.
Please help me. For two years I was living (if you can even call it that) with candidiasis. I believe it’s under control now, but I exhibit all the symptoms of excessive glutamate and insufficient GABA. I’ve read through your compilations regarding this topic, but I’m suffering from confusion, fatigue, anxiety, and other maladies. It’s taken me quite some time to gather the faculties needed to even write this message. I would be eternally grateful if you would spare even a few minutes to consult me on what feels to be an insurmountable condition.
Would be happy to consult with you. My fees and options can be found on the following page.
I am researching a cure or help with tinnitus and I landed on your page from an article that was shared on a forum I belong to. Do you have any insights for me on things to try? I am thinking that it could possibly be caused by high glutamate or some kind of imbalance in the brain.
There can be many causes of tinnitus. However, high histamine is one possibility. You can read about histamine on the following page.
Other common cause is SIBO, which you can read about on this page.