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Is Threelac Safe and Effective?

Enterococci in Threelac

Threelac is one of the most popular Candida treatment products on the market today, but I have some serious questions about its safety.

I tried the product myself a couple years ago and had a very negative experience. I developed what I believe was a bacterial infection. It gave me a high fever, sore throat, chills, shivers, shakes, sweats, and a severe vaginal yeast infection.

My adult son tried it as well and he got much sicker than I did. His fever was very high, sore throat, chills, migraine, and sweats. He tells me he was so sick he couldn’t get out of bed for two days.

I was rather perplexed and quite disappointed in our experience because I had heard such great things about it and I was really hopeful that it was going to be effective. Before buying the product, I had done a little research, and at the time, I couldn’t find any bad reviews about it.

At first, I thought our experience was unique, so I just chalked it up to our body chemistry for the time being. However, as time went on I discovered more facts that raised quite a few questions.

Over at Candida forum I found quite a few people who shared bad experiences and opinions about the product and some even feel it is a scam.

The most disturbing fact I stumbled upon is that Threelac contains a bacteria called Enterococcus faecalis. This is an opportunistic gram-positive bacterium that can make you very sick. A lot of countries, like Australia and Canada, don’t allow products that contain this bacteria in their country. Enterococci are consistently the second or third most common culprit in urinary tract infections, wound infections, and bacteremia in hospitals and are involved in a significant percent of endocarditis. You can learn more about Enterococcus faecalis on the following page.

There’s a great deal of disagreement in the alternative health field over this ingredient and proponents of Threelac argue that they use a different strain that is supposedly not harmful. Well, my feeling is that even if that’s true, I wouldn’t want to take the risk of any strain. My own experience proved to me that my body developed an infection.

I decided that people should really know that not everyone is having great experiences with Threelac and I posted my review of Threelac on my site so that people could hear both sides of the story and make an informed decision.

After I posted my review on my site, I started to get quite a few customers who shared with me that they got very sick from taking Threelac. I also get a lot of emails from people who thank me for sharing my honest experience and say they have experienced the same thing.

Last week I received an email from someone who says that when they started taking Threelac it gave them stabbing pain in their perineum, the shakes and shivers, sweating, inability to sleep, burning throat and burning in the left eye. Not only that, after they stopped taking it, the symptoms continued. They can’t make it go away.

I find this very disturbing. What the heck is going on here? Why is it that some people have no negative reactions and other people have violent reactions?

Well, I still believe it basically boils down to body chemistry and vulnerability. I think it depends on how severe you’re Candida overgrowth is and how susceptible you are to not only the bacteria that is in the product, but also the yeast and sugars which are added to feed the bacteria. It appears that some bodies, perhaps ones that have a weaker immune system, leaky gut, or a less functional liver are prone to develop an infection when exposed to this bacteria, while other people with a stronger constitution may have no problem.

Proponents of the product feel the negative symptoms must be die-off, but I disagree. I’ve been dealing with Candida for more than 20 years and I’ve taken about every product out there and endured some horrific die-off, but I have never experienced what I felt with this product. What I had was clearly a bacterial infection.

Additionally, I received an email from another holistic health professional who had the same experience as mine and she told me that Threelac’s own information states that the product should not be used if you have leaky gut syndrome. I don’t have a package of Threelac to read and verify if that’s true, but if it is, that’s absurd. Almost anyone with severe Candida overgrowth has leaky gut syndrome. She concluded that the leaky gut allows the bacteria in Threelac to enter the bloodstream and becomes pathogenic at that point. Which sounds like another logical explanation.

I don’t recommend Threelac to anyone, because I think it’s better to be safe than sorry. Maybe you’ll be one of those who will be okay with it and maybe you won’t. I would exercise extreme caution before giving it a try, but that’s my particular preference. However, you’ll find many holistic and alternative health practitioners who do recommend it freely.

I recommend caution not only in regard to Threelac but any new product you haven’t tried. Always do a little research and see what other people saying. The alternative health field is not immune to scams or ineffective treatment. Unfortunately, the fact that so many people are now taking an interest in alternative and holistic medicine, this makes it even more vulnerable. I’m not saying that is the case with this particular product, I’m just saying that it’s always best to be an aware and informed consumer regardless of what product you’re considering.

If you need more personal help dealing with any aspect of Candida, I offer consultations by phone. You can find out more by visiting my counseling page.

You may also want to look at my newest book on Candida, which is now available in paperback and goes into great detail about probiotics.

Alternatively, I have a handy little ebook called Candida Secrets that covers all the basics and comes with recipes, meal plans, and tips for staying on the diet.

How about you, has it made you sick? Do you have a Threelac experience you’d like to share? Leave your comments below.

Holistic Health Coaching with Cynthia

{ 169 comments… add one }
  • Debbie Downie March 2, 2013, 2:01 pm

    Did you take Threelac and then the Oil of Oregano to clear your body of the Enterococcol Faecalis? Also, why zinc with the Oil of Oregano? Oh and what dosage did you take? Thank you!

  • Mani March 3, 2013, 7:02 pm

    To Debbie Downie!

    Hi Debbie,

    Thanks for the reply!!!

    I took Threelac in July 2012 and I lost 2 stone in December 2012, then had massive malabsorbtion issue and then my inability to sleep!!! Along with other issues like clammy hands and feet and even worse sinus problems!!… Aching joints etc, dizziness and blurred vision !!! For three months I have had this!!,… But with Oil of Oregano (4 drops in half a tumbler of water three times a day) helped some, as I sleep for 4 hours now and Zinc at the same ratio!!!… Also Vitamin B12 and Magnesium have now been added!!… Do you have other Candida problems also???… And how is your mental position??…Anxiety etc?… keep in touch so we can help each other!!… Are you in UK or US ?

  • Admin - Cynthia Perkins March 11, 2013, 3:24 pm

    Debbie and Mani,

    Oregano oil is a powerful antifungal, so it may have made you feel better because it was also killing Candida, not just the bacteria. The same is true of zinc. Zinc deficiency can be a significant contributing factor to Candida overgrowth and many other viruses, bacteria etc. Zinc is a natural antibiotic, antiviral and antifungal. If the body does not have adequate levels of zinc, the immune system cannot fight off unfriendly organism like candida and bacteria.

    It’s also important to be aware that you should not take zinc for an extended period of time without also taking copper, or you can cause a copper deficiency, which can result in a variety of other negative impacts on things like neurotransmitter function, energy production, cardiovascular health and more.


  • Mani March 13, 2013, 8:18 pm

    Hi Cynthia,

    Do you think that we have harmed ourselves permanently with Enterococcal Faecalis or Faecium as in Threelac and Sumbion???

    As my bloatedness and other issues have gone sore throat and sinus congestion along with Muscular aches and ear problems!!! However my patchy white tongue has gone… But still have sleeping and now mental issues…. Please help!!!!

  • Debbie March 14, 2013, 6:58 pm

    Thank you for your comment and all the good information! So thankful for this site. Hopefully people will find it before buying a product that may hurt them! Wish I would have found this before using the Symbion.

  • Admin - Cynthia Perkins March 15, 2013, 3:17 pm

    Hi Mani,

    I doubt it, but I can’t say for sure. Those are symptoms of yeast overgrowth as well, so it may simply be that your yeast is worse. Plus there are many other contributing factors for mental health issues and sleeping. I have hundreds of pages on these topics, so I suggest you use the search function on the blog and the site and explore some of the other possibilities. If you would like more personal advice, then you should consider a phone consultation.

    You’re welcome, Debbie. I would also suggest you use the search function to explore the issues you are having as well.

    For example, for both of you, here are some pages to get started on:


  • Lanna April 14, 2013, 6:30 pm

    I came across your site when i was searching side effects of fivelac. I tried it about 2 years ago to help with candida and it worked really really well, many of my symtoms disappeared and i started to feel healthy again. I then stopped taking it and went back to a not so great diet. In time all my symtpoms came back so i recently bought some more fivelac. I had been taking it for about 2 weeks and then i noticed a pain in my stomach, i woke up on saturday with excrutiating pain in my stomach and right side and have spent the weekend in hot and cold sweats and pain. I do not think these are die off symptoms as i had nothing like this the last time i used fivelac and think that it has to be caused by the fivelac. I just don’t understand how it worked perfectly for me 2 years ago and now my body can’t seem to handle it. anyway i have stopped taking it and have an appointment with the doctor tomorrow,i think i have some kind of infection from it. Next time i think i will try some regular probiotics and a strict diet…or maybe the oil of oregano. Do you have to take zinc with the organo oil, or can you take it alone?

  • Admin - Cynthia Perkins April 18, 2013, 9:41 pm


    Zinc can be taken anytime.


  • Zeinab August 18, 2013, 12:03 am

    Dear Cynthia:

    I recently bought for my autistic son some threelac. I began giving it him on and off but usually with multivitamins and fish oil. I stopped all the other vitamins except for the threelac and the fish oil which I have been giving to him for the last three days. Two days into one packet a day with the fish oil, I thought that my son was coming with a cold. he cant tell me sometimes what is bothering him but he made m touch his head and he was really in a lot of pain that I freaked. I stopped giving it to him today but today I took him to the park and he was really sacred of walking on the grass which has been no problem for him. it seems his sensitivity to grass has really increased to the extent that he wants me to carry him . he is 8 yrs old. I think it is the threelac and he is still like he is having a cold very quite and looks sick

  • Admin - Cynthia Perkins August 22, 2013, 9:22 pm

    Well it is hard to say for sure if it is the Threelac, because it was taken with other products at the same time. Some people respond negatively to fish oil. The fish oil may have got neurotransmitters moving too much for him. But it is possible it was the Threelac disrupting neurotransmitters and increasing bacteria or yeast. It’s hard to say. I’m sorry for your setback. If it were me, I would stop everything and give it a little time. Then resume fish oil later without Threelac so you can observe what happens. It is always best to try new supplements one at a time, so you can know for sure if it is having a negative impact.


  • Tony January 9, 2014, 10:15 pm

    I wish that I would have seen your page before purchasing threelac.
    If we have a bad bacteria in our system, would it not make sense that they would not need to add one???
    I started taking threelac and in just a few days started experiencing extremely bad heart burn and pain in my stomach.
    I think this product should be avoided!!!

  • Tony January 9, 2014, 10:17 pm

    By the way, I ordered your product 🙂

  • Jill Farris July 22, 2014, 9:37 pm

    I recently got back on Three lac after many years of not taking it. I have been sick with fever and achey joints four times in three months. I kept thinking about when in my life I have been sick like this and I realized it was back when I was taking Three Lac.

    Thank you for addressing the problems of Three Lac. I am throwing the rest of it out.

  • mojca April 22, 2015, 11:56 am

    Hi Cynthia,

    I took Threelac for a course if about 4 months five or six years ago, along with a strict diet and it worked well, I didn’t have any negative reaction.
    I did go back to some sugars in my diet since and have had a relapse in symptoms a few times, I researched online and found another product that is apparently new, would you have any advice on it’s safety? It’s called Lufenuron and there are apparently a lot of scammers that sell pesticide grade Lufenuron instead of pharmaceutical grade as they claim. Thank you!

  • Admin - Cynthia Perkins May 26, 2015, 9:15 pm

    Hi Mojca,

    That’s a good question. I’ve been meaning to write a post on lufenuron, so I have done so now and answered your question there. You can find it on the following page.


  • Amy August 5, 2015, 4:31 am

    Hi, my 6 year old son was diagnosed with candida a few months ago as he had a really bad rash on his butt that would not go away to a point where it would ooze. Our doctor prescribed him nystatin and told me to get threelac to give him as well. The first week my had a high fever, his muscles in his legs started twitching/spasming and he wasn’t himself at all. There were a few incidences where when he was half asleep and we were putting him in bed he went into a crazy state where he was panicing, holding his head in pain, trying to run out of our arms, and screaming from the top of his lungs. He would then snap out of it after about 5-10 minutes of that horrible state and not remember a thing that just had happened. So we immediately called the doctor and he said they are all normal side effects as it was yeast die off. He only recommended to cut the nystatin dosage in half which we did. These effects only happened the first 10 days of the treatment and then everything was normal after. Until just the other day, almost a month and a half into the same treatment, we are almost finished with the nystatin and take a packet a day of the threelac and the rash is just nearly gone he woke up in the middle of the night with horrible stomach pain. The following morning he was puking uncontrollably and couldn’t keep anything down and had horrible pain. It went through the night to the following day. We took him into the ER as he was in so much pain and so pale and lifeless. They said it was probly just a stomach virus, gave him an anti-Nausea pill and released him. That same evening he had one of those spastic nightmares when getting him to bed and it was worse than ever before and I hope it does not continue Not sure what to do from here? Any advise will be so helpful!

  • John Bishoy September 14, 2016, 11:32 am

    Thanks for sharing this vital testimony, just in time to avoid a catastrophe.

    I already purchased a package from GlobalHealthTrax and waited a few days to finish another natural product and I came across your experience.

    Although I suffer from severe intestinal Candida, and tried several probiotic formulas, one of them made me sick and contained Bacillus Subtilis, it gave me diarrhea and severe stomach cramps that lasted for days.

    I did not want to risk getting an incurable infection using the yet non proven safe Enterococcus Faecalis bacteria. It is absolutely true better be safe than sorry.

  • Janet McFadden January 16, 2018, 10:35 am

    Thanks for this information. I’ve been taking Three-Lac for a few months and my CFS has become increasingly worse — I suddenly wondered if it could be due to this product. Your review was very informative and helpful!!!

  • Amy November 21, 2020, 4:20 pm

    Wow! I just began taking ThreeLac three days ago & now I’m scared. Testing revealed I am riddled with Candida albicans & I visited Mark & Alyson Cobb’s Candida free website & went with their recommendation.
    My tummy bubbled & I was burby & gassy very quickly upon my first powder dose. I could just feel something sitting there in my stomach bubbling away. So far I’ve had very mild stabbing stomach pain, a stimulated appetite (which seems to have passed now), a change in the frequency & texture of bowel movements & increased thirst.
    This morning my sinuses have completely dried out, I’m very thirsty & not hungry at all. The Cobbs recommend starting off very slowly with one packet a day for up to 6 weeks. Alyson responded to my email about stimulated appetite advising it would be temporary & to roll with the mild die off symptoms & not worry too much.
    My big issues are mucosal dysbiosis- constant ‘snotty’ nose & allergies (hay fever), recurrent BV & susceptibility to thrust (fun times ?).
    How long will it take for it to be obvious they ThreeLac is potentially messing me up? I’m hedging my bets that I will be one of the people that does OK on it. For all my snottiness I don’t get colds of flu & I’m robust with a strong constitution. No food allergies or sensitivities & a lot of things such as acne, mild eczema & irregular cycles etc. have cleared up over the years due to diet & lifestyle initiatives (they weren’t enough to knock the Candida though).

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